Are there any concerns or considerations?

Effective dose and co-ingredient risk

• Optimal, threshold, and minimal effective dose and bioavailability of the native and advanced available compounds remain to established.
• Advanced formulations often carry additive and adjunct compounds that may be bioactive. Sports dietitians and athletes should be cautious in regards to inadvertent doping.
• Turmeric extracts contain active non-curcuminoid fractions of polysaccharides (turmrerosacchardies) and Turmeric oils. There is weak evidence for the efficacy of these products (Turmacin®) in improving pain threshold and range of motion in healthy participants.²⁶

Unknown effects of long-term use on training response

As with some other compounds that dampen the oxidative and pro-inflammatory response to exercise (e.g Vitamin E), the possibility of reducing the training-response signal for adaptation requires systematic investigation. Until this work is complete, coaches and athletes should be aware that the long-term effects of curcumin on training adaptation is unknown.