Name / Formulation and description:
Prebiotics: A prebiotic is defined as ‘a substrate that is selectively utilized by host microorganisms conferring a health benefit.’1
Sources include ‘prebiotic-like’ foods and products that contain (one or more) concentrated extracts. Fructo -oligosaccharides (FOS), galacto-oligosaccharides (GOS), soybean- oligosaccharides, mannan oligosaccharides, xylo-oligosaccharides, inulin, partially hydrolysed guar gum, lactulose, and resistant starches (types 1, 2, 3, and 4).
The doses used in studies demonstrating a significant alteration in microbial composition and metabolism, vary greatly and are individual-microbiome dependent.
Current AIS Supplement Framework Classification: N/A Agreed AIS Supplement Framework Classification: Group B
Supplement-fact-sheet-Prebiotics.pdf
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Prebiotics are substrates selectively utilised by the host microbiome conferring a health benefits to the host. They may:
Consumption of prebiotic like foods and/or prebiotic supplements balance and restore a dysbiotic gastrointestinal environment caused by negative factors including diet, certain medication use, physical and psychological stressors.
While complex, it is thought they do this by increasing microbial diversity and key bacterial species that produce a variety of end products including short chain fatty acids.
Prebiotic mechanisms:
Most human studies evaluating the effects of prebiotics have explored effects on the composition of the gastrointestinal microbiota. These studies report significant increases in Bifidobacterium and to a lesser-degree Lactobacillus bacterium and Faecalibacterium prausnitzi, Roseburia and Eubacterium spp. and their by-products.
The main prebiotics researched are fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), lactulose and partially- hydrolysed guar gum.
Taking Lactulose, GOS and FOS have all been found to be effective in the management of constipation. GOS have been found to reduce the incidence of ‘traveller’s diarrhoea and FOS to reduce the severity of diarrhoea.
Administration of lactulose or oligofructose-enriched inulin has been found to reduce beta-glucuronidase activity (protective against colon cancer).
Lactulose has been shown to reduce incidence of urinary tract infections.
Inulin plus oligofructose has been shown to significantly improve calcium absorption in women. and promote satiety
Group C